DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12] — image 1 of 3

Product details

DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12]

Catalog number ET1705-12

Price for ET1705-12

Size / count 100 µL

About this product

DNA polymerase beta, also known as POLB, is an enzyme present in eukaryotes. In humans, it is encoded by the POLB gene. In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. The mitochondrial DNA of mammalian cells is constantly under attack from oxygen radicals released during ATP production. Mammalian cell mitochondria contain an efficient base excision repair system employing POLB that removes some frequent oxidative DNA damages. POLB thus has a key role in maintaining the stability of the mitochondrial genome. An analysis of the fidelity of DNA replication by polymerase beta in the neurons from young and very aged mice indicated that aging has no significant effect on the fidelity of DNA synthesis by polymerase beta. This finding was considered to provide evidence against the error catastrophe theory of aging.

Specifications

Catalog number: ET1705-12
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: DNA directed DNA polymerase beta antibody DNA pol beta antibody DNA polymerase beta antibody DNA polymerase beta subunit antibody DPOLB_HUMAN antibody MGC125976 antibody Pol B antibody Pol beta antibody POLB antibody Polymerase (DNA directed) beta antibody
Abbreviation: POLB
Swiss Prot: P06746 Human, Q8K409 Mouse, P06766 Rat
Cellular Locus: Nucleus, Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat, Zebrafish
Immunogen: Synthetic peptide within Human DNA Polymerase beta aa 286-335 / 335.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IF-Cell, IP
Positive Control: PC-12 cell lysate, NIH/3T3 cell lysate, A431 cell lysate, zebrafish tissue lysates, rat lung tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human uterus tissue, mouse cerebellum tissue, K-562.
Concentration: 1 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:20-1:50 ;IP: 1:10-1:20
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 38 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12]?

The catalog number for DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12] is ET1705-12.

What sizes are available for DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12]?

DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12] is available in the following size(s): 100 µL.

Is DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12] in stock?

DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DNA Polymerase beta Recombinant Rabbit Monoclonal Antibody [JM93-12] used for?

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.