MUC4 Recombinant Rabbit Monoclonal Antibody [JM19-36]

About this product

Mucin 4 (MUC 4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC-4 is a high-molecular weight glycoprotein. The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation.

Specifications

Catalog number

ET1705-13

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Ascites sialoglycoprotein 1 antibody Ascites sialoglycoprotein 2 antibody Ascites sialoglycoprotein antibody ASGP antibody ASGP-1 antibody ASGP-2 antibody HSA276359 antibody MUC 4 antibody MUC-4 antibody Muc4 antibody MUC4_HUMAN antibody Mucin 4 antibody Mucin 4 cell surface associated antibody Mucin 4 tracheobronchial antibody Mucin-4 beta chain antibody Pancreatic adenocarcinoma mucin antibody Testis mucin antibody Tracheobronchial mucin antibody Tracheobronchial mucin Fragment antibody

Abbreviation

MUC-4, ASGP, ASGP-1, ASGP-2, MUC4

Swiss Prot

Q99102 Human

Cellular Locus

Secreted, Cell membrane and Membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant protein within Human MUC4 aa 4,751-4,950 / 5,412.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Rat brain tissue, human lung carcinoma tissue, human colon tissue, human stomach carcinoma tissue, A549.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 542 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes