Calretinin Recombinant Rabbit Monoclonal Antibody [JM12-93]

About this product

Calretinin, also known as calbindin 2 (formerly 29 kDa calbindin), is a calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. Calretinin is abundantly expressed in neurons including retina (which gave it the name) and cortical interneurons. Expression was found in different neurons than that of the similar vitamin D-dependent calcium-binding protein, calbindin-28kDa. Calretinin has an important role as a modulator of neuronal excitability including the induction of long-term potentiation. Loss of expression of calretinin in hippocampal interneurons has been suggested to be relevant in temporal lobe epilepsy. It is expressed in a number of other locations including hair follicles.

Specifications

Catalog number

ET1705-19

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

29 kDa calbindin antibody CAB 29 antibody CAB29 antibody CAL 2 antibody CAL2 antibody CALB 2 antibody CALB2 antibody CALB2_HUMAN antibody Calbindin 2 29kDa antibody Calbindin 2 antibody Calbindin D29K antibody Calbindin2 antibody Calretinin antibody CR antibody

Abbreviation

CR, CALB2, CAB29

Swiss Prot

P22676 Human, Q08331 Mouse, P47728 Rat

Cellular Locus

Cytosol, dendrite, gap junction, nucleus, parallel fiber to Purkinje cell synapse, synapse, terminal bouton.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human Calretinin aa 60-100.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IHC-Fr, IF-Tissue

Positive Control

Mouse brain tissue lysate, rat brain tissue lysate, mouse hippocampus tissue lysate, rat hippocampus tissue lysate, human brain tissue, mouse brain tissue, rat brain tissue, mouse hippocampus tissue, mouse cerebral cortex tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IHC-P: 1:5,000 ;IHC-Fr: 1:100 ;IF-Tissue:1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 32 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes