CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] — image 1 of 3

Product details

CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23]

Catalog number ET1705-28

Price for ET1705-28

Size / count 100 µL

About this product

Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra. CYP2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs, via the addition or removal of certain functional groups – specifically, hydroxylation, demethylation, and dealkylation. CYP2D6 also activates some prodrugs. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver.

Specifications

Catalog number: ET1705-28
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CPD6 antibody CYP2D antibody CYP2D6 antibody CYP2D7AP antibody CYP2D7BP antibody CYP2D7P2 antibody CYP2D8P2 antibody CYP2DL1 antibody CYPIID6 antibody Cytochrome P450 DB1 antibody Cytochrome P450 family 2 subfamily D member 6 antibody Cytochrome P450 family 2 subfamily D polypeptide 6 antibody Debrisoquine 4 hydroxylase antibody Flavoprotein linked monooxygenase antibody Microsomal monooxygenase antibody P450 DB1 antibody P450C2D antibody P450DB1 antibody Xenobiotic monooxygenase antibody
Abbreviation: Cytochrome P450 2D6, CYP2D6, CYP2DL1
Swiss Prot: P10635 Human
Cellular Locus: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human CYP2D6 aa 301-497 / 497.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, FC
Positive Control: HepG2 cell lysates, HepG2, SW480, human liver tissue, human kidney tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 56 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23]?

The catalog number for CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] is ET1705-28.

What sizes are available for CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23]?

CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] is available in the following size(s): 100 µL.

Is CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] in stock?

CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] is currently made to order / not held in immediate stock. Contact us for lead time.

What is CYP2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] used for?

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.