Protein C Recombinant Rabbit Monoclonal Antibody [JM93-61]

About this product

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIX, is a zymogen, that is, an inactive enzyme. The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease since it contains a residue of serine in its active site. The zymogenic form of protein C is a vitamin K-dependent glycoprotein that circulates in blood plasma. Its structure is that of a two-chain polypeptide consisting of a light chain and a heavy chain connected by a disulfide bond. The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs). Because of EPCR's role, activated protein C is found primarily near endothelial cells (i.e., those that make up the walls of blood vessels), and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of resistance to APC, suffer from a significantly increased risk of forming dangerous blood clots (thrombosis).

Specifications

Catalog number

ET1705-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Activation peptide antibody Anticoagulant protein C antibody APC antibody Autoprothrombin IIA antibody Blood coagulation factor XIV antibody EC 3.4.21.69 antibody PC antibody proC antibody PROC_HUMAN antibody PROC1 antibody Protein C (inactivator of coagulation factors Va and VIIIa) antibody THPH3 antibody THPH4 antibody Vitamin K dependent protein C antibody

Abbreviation

PROC

Swiss Prot

P04070 Human

Cellular Locus

Endoplasmic reticulum, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Protein C aa 290-380 / 461.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Hela, 293T, human liver tissue, human kidney tissue, human stomach carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 52 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes