ACE Recombinant Rabbit Monoclonal Antibody [JM59-32]

About this product

Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II. Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases. Other lesser known functions of ACE are degradation of bradykinin, substance P and amyloid beta-protein. ACE hydrolyzes peptides by the removal of a dipeptide from the C-terminus. Likewise it converts the inactive decapeptide angiotensin I to the octapeptide angiotensin II by removing the dipeptide His-Leu. Angiotensin II is a potent vasoconstrictor in a substrate concentration-dependent manner. Angiotensin II binds to the type 1 angiotensin II receptor (AT1), which sets off a number of actions that result in vasoconstriction and therefore increased blood pressure. ACE is also part of the kinin-kallikrein system where it degrades bradykinin, a potent vasodilator, and other vasoactive peptides. Kininase II is the same as angiotensin-converting enzyme. Thus, the same enzyme (ACE) that generates a vasoconstrictor (ANG II) also disposes of vasodilators (bradykinin).

Specifications

Catalog number

ET1705-36

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

ACE 1 antibody ACE antibody ACE T antibody ACE_HUMAN antibody ACE1 antibody Angiotensin converting enzyme somatic isoform antibody Angiotensin converting enzyme testis specific isoform antibody Angiotensin I converting enzyme 1 antibody Angiotensin I converting enzyme antibody Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript antibody Angiotensin-converting enzyme antibody Carboxycathepsin antibody CD 143 antibody CD143 antibody CD143 antigen antibody DCP 1 antibody DCP antibody DCP1 antibody Dipeptidyl carboxypeptidase 1 antibody Dipeptidyl carboxypeptidase I antibody Kininase II antibody MGC26566 antibody MVCD3 antibody Peptidase P antibody Peptidyl dipeptidase A antibody soluble form antibody Testicular ECA antibody

Abbreviation

ACE, DCP, DCP1

Swiss Prot

P12821 Human, P09470 Mouse

Cellular Locus

Secreted. Cell membrane. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human ACE aa 1,257-1,306 / 1,306.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Human lung tissue lysate, mouse lung tissue lysate, mouse kidney tissue lysate, human kidney tissue, mouse testis tissue, mouse kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:100-1:500 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 150 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes