PI 3 Kinase p110 delta Recombinant Rabbit Monoclonal Antibody [JM83-24]

About this product

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene. p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmunity and transplant rejection. Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110α, p110β and p110γ. p110α and p110β interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.

Specifications

Catalog number

ET1705-46

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

5-bisphosphate 3-kinase 110 kDa catalytic subunit delta antibody 5-bisphosphate 3-kinase catalytic subunit delta isoform antibody APDS antibody GRB1 antibody IMD14 antibody p110d antibody p110delta antibody p110dp85a antibody p85-ALPHA antibody Phosphatidylinositol 3 kinase catalytic delta polypeptide antibody Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform antibody Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta antibody Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta antibody Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform antibody Phosphatidylinositol-4 antibody Phosphoinositide 3 kinase B antibody Phosphoinositide 3 kinase C antibody Phosphoinositide 3 kinase catalytic delta polypeptide antibody Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta antibody PI3 kinase p110 subunit delta antibody PI3-kinase subunit delta antibody PI3K antibody PI3K-delta antibody PI3Kdelta antibody Pik3cd antibody PIK3R1 antibody PK3CD antibody PK3CD_HUMAN antibody PtdIns 3 kinase p110 antibody PtdIns 3 kinase subunit p110 delta antibody PtdIns-3-kinase subunit delta antibody PtdIns-3-kinase subunit p110-delta antibody

Abbreviation

PI3-kinase subunit delta, PI3K-delta, PI3Kdelta, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit p110-delta, p110delta, PIK3CD

Swiss Prot

O00329 Human, O35904 Mouse, D4A5Q1 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PI 3 Kinase p110 delta aa 197-246 / 1044.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Raji cell lysate, Jurkat cell lysate, RAW264.7 cell lysate, Mouse spleen tissue lysate, Rat spleen tissue lysate, rat spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 119 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes