BMAL1 Recombinant Rabbit Monoclonal Antibody [JM17-34]

About this product

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or Brain and Muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the Bmal1 gene, also known as ARNTL, MOP3, and, less commonly, BHLHE5, BMAL, BMAL1C, JAP3, PASD3, and TIC. BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human Arntl gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome. The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that Bmal1 is the only clock gene without which the circadian clock fails to function in humans. Bmal1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in Bmal1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.

Specifications

Catalog number

ET1705-5

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ARNT like protein 1 brain and muscle antibody Arntl antibody Aryl hydrocarbon receptor nuclear translocator like antibody Aryl hydrocarbon receptor nuclear translocator like protein 1 antibody Aryl hydrocarbon receptor nuclear translocator-like protein 1 antibody Basic helix loop helix PAS orphan MOP3 antibody Basic helix loop helix PAS protein MOP3 antibody Basic-helix-loop-helix-PAS protein MOP3 antibody bHLH PAS protein JAP3 antibody bHLH-PAS protein JAP3 antibody bHLHe5 antibody BMAL 1 antibody BMAL1_HUMAN antibody BMAL1c antibody Brain and muscle ARNT like 1 antibody Brain and muscle ARNT-like 1 antibody CG8727 PA antibody Class E basic helix-loop-helix protein 5 antibody cycle antibody JAP 3 antibody JAP3 antibody Member of PAS protein 3 antibody Member of PAS superfamily 3 antibody MGC47515 antibody MOP 3 antibody MOP3 antibody PAS domain-containing protein 3 antibody PASD 3 antibody PASD3 antibody TIC antibody

Abbreviation

bHLHe5, ARNTL, BHLHE5, BMAL1, MOP3, PASD3

Swiss Prot

O00327 Human, Q9WTL8 Mouse, Q9EPW1 Rat

Cellular Locus

Nucleus, PML body, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human BMAL1 aa 550-599 / 626.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue

Positive Control

Hela cell lysate, NIH/3T3 cell lysate, rat brain tissue lysate, mouse spleen tissue lysate, Hela, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 69 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes