Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37] — image 1 of 3

Product details

Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37]

Catalog number ET1705-51

Discontinued

Price for ET1705-51

Size / count 100 µL

This variant is discontinued and cannot be added to your cart.

About this product

Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children.

Specifications

Catalog number: ET1705-51
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
CAS Number: 9000-83-3
Product Name Alternative: 9130019I15Rik antibody FLJ34389 antibody hMLKL antibody Mixed lineage kinase domain like antibody Mixed lineage kinase domain like protein antibody Mixed lineage kinase domain like pseudokinase antibody Mixed lineage kinase domain-like protein antibody Mlkl antibody MLKL_HUMAN antibody
Abbreviation: Mlkl
Swiss Prot: Q9D2Y4 Mouse
Cellular Locus: Cell membrane, Cytoplasm, Nucleus.
Host: Rabbit
Species Reactivity: Mouse
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser345 of mouse MLKL aa 314-363 / 472.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IHC-Fr
Positive Control: L929 treated with 20μM Z-VAD for 3.5 hours then added 100nM SM-164 and 20ng/ml TNF-α for 3 hours cell lysate, mouse spleen tissue, mouse lung tissue, mouse liver tissue, mouse colon tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:50-1:100 ;IHC-Fr: 1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 54 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37]?

The catalog number for Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37] is ET1705-51.

Is Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37] in stock?

Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37] used for?

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.