- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
![Ferritin Light Chain Recombinant Rabbit Monoclonal Antibody [JM10-37] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea8219d/imageurl/et1705-54.webp)
Product details
Catalog number ET1705-54
Price for ET1705-54
Size / count 100 µL
Mammalian ferritins consist of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts. The gene encoding human ferritin heavy chain maps to chromosome 11q13 and the human ferritin light chain gene maps to chromosome 19q13.3-q13.4.
The catalog number for Ferritin Light Chain Recombinant Rabbit Monoclonal Antibody [JM10-37] is ET1705-54.
Ferritin Light Chain Recombinant Rabbit Monoclonal Antibody [JM10-37] is available in the following size(s): 100 µL.
Ferritin Light Chain Recombinant Rabbit Monoclonal Antibody [JM10-37] is currently made to order / not held in immediate stock. Contact us for lead time.
Mammalian ferritins consist of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the n
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.
