Ferritin Heavy Chain Recombinant Rabbit Monoclonal Antibody [JM22-36]

About this product

Mammalian ferritins consist of 24 subunits made up of two types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of FeII, whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of FeIII. The most prominent role of mamma-lian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.

Specifications

Catalog number

ET1705-55

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Apoferritin antibody Cell proliferation inducing gene 15 protein antibody Cell proliferation-inducing gene 15 protein antibody F HC antibody Ferritin H subunit antibody Ferritin heavy chain antibody Ferritin heavy polypeptide 1 antibody FHC antibody FRIH antibody FRIH_HUMAN antibody FTH 1 antibody FTH antibody FTH1 antibody FTH1 protein antibody FTHL 6 antibody FTHL6 antibody Iron overload autosomal dominant antibody MGC104426 antibody N-terminally processed antibody OK/SW-cl.84 antibody PIG 15 antibody PIG15 antibody Placenta immunoregulatory factor antibody PLIF antibody Proliferation inducing gene 15 protein antibody Proliferation inducing protein 15 antibody

Abbreviation

Ferritin H subunit, FTH1, FTH, FTHL6

Swiss Prot

P02794 Human

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal human Ferritin Heavy Chain.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P

Positive Control

Human kidney tissue, human liver tissue, human placenta tissue.

Concentration

1 mg/mL

Dilution

IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 21 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes