KPNA2 Recombinant Rabbit Monoclonal Antibody [JM90-33]

About this product

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Specifications

Catalog number

ET1705-61

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

IMA1_HUMAN antibody Importin alpha 1 antibody Importin alpha 2 antibody Importin alpha 2 subunit antibody Importin alpha P1 antibody Importin subunit alpha-1 antibody IPO A1 antibody IPOA 1 antibody IPOA1 antibody Karyopherin alpha 2 antibody Karyopherin alpha 2 RAG cohort 1 antibody Karyopherin alpha 2 subunit antibody Karyopherin subunit alpha-2 antibody KPNA2 antibody KPNA2 protein antibody Pendulin antibody QIP 2 antibody QIP2 antibody RAG cohort 1 antibody RAG cohort protein 1 antibody RCH 1 antibody RCH1 antibody SRP 1 antibody SRP1 alpha antibody SRP1 antibody SRP1-alpha antibody SRP1alpha antibody

Abbreviation

KPNA2, RCH1, SRP1

Swiss Prot

P52292 Human, P52293 Mouse, Q6P6T9 Rat

Cellular Locus

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human KPNA2 aa 41-90 / 529.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC

Positive Control

Hela cell lysate, 293T cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, 293T.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 58 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes