STING Recombinant Rabbit Monoclonal Antibody [JM03-47]

About this product

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Specifications

Catalog number

ET1705-68

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

endoplasmic reticulum IFN stimulator antibody Endoplasmic reticulum interferon stimulator antibody ERIS antibody FLJ38577 antibody hMITA antibody hSTING antibody Mediator of IRF3 activation antibody MITA antibody Mitochondrial mediator of IRF3 activation antibody MPYS antibody N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody NET23 antibody Stimulator of interferon genes antibody Stimulator of interferon genes protein antibody STING antibody TM173_HUMAN antibody Tmem173 antibody Transmembrane protein 173 antibody

Abbreviation

hSTING, ERIS, hMITA, TMEM173, ERIS, MITA, STING

Swiss Prot

Q86WV6 Human, F1M391 Rat

Cellular Locus

Endoplasmic reticulum membrane, Cytoplasm, perinuclear region, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Cytoplasmic vesicle, autophagosome membrane, Mitochondrion outer membrane, Cell membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant protein within human STING aa 117-379.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC, IF-Tissue, IP

Positive Control

THP-1 cell lysate, SW620 cell lysate, human lung tissue lysate, THP-1, human tonsil tissue, rat lung tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:1,000 ;IF-Tissue: 1:200 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes