JAK1 Recombinant Rabbit Monoclonal Antibody [JM75-03]

About this product

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at position 1022 and 1023 is believed to function in the activation of catalytic events. The canonical JAK-Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering JAK-Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Specifications

Catalog number

ET1705-84

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

JAK 1 antibody JAK 1A antibody JAK 1B antibody JAK-1 antibody JAK1 antibody JAK1_HUMAN antibody JAK1A antibody JAK1B antibody Janus kinase 1 (a protein tyrosine kinase) antibody Janus kinase 1 antibody JTK3 antibody Tyrosine protein kinase JAK 1 antibody Tyrosine protein kinase JAK1 antibody Tyrosine-protein kinase JAK1 antibody

Abbreviation

JAK-1, JAK1A, JAK1B

Swiss Prot

P23458 Human, P52332 Mouse, G3V9W2 Rat

Cellular Locus

Endomembrane system.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human JAK1 aa 621-670 / 1,154.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC, IF-Cell, IF-Tissue

Positive Control

HeLa cell lysate, SW480 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, human kidney tissue, mouse kidney tissue, mouse large intestine tissue, SW480.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:200-1:2,000 ;FC: 1:50-1:100 ;IF-Cell: 1:100 ;IF-Tissue: 1:50-1:400

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 133 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes