TLR2 Recombinant Rabbit Monoclonal Antibody [JM22-41]

About this product

The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of TLR family, it induces NFkB signaling upon activation.

Specifications

Catalog number

ET1705-92

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

CD282 antibody CD282 antigen antibody TIL 4 antibody TIL4 antibody TLR 2 antibody TLR2 antibody TLR2_HUMAN antibody Toll like receptor 2 antibody Toll like receptor 2 precursor antibody Toll-like receptor 2 antibody Toll/interleukin 1 receptor like 4 antibody Toll/interleukin 1 receptor like protein 4 antibody Toll/interleukin receptor like protein 4 antibody Toll/interleukin-1 receptor-like protein 4 antibody

Abbreviation

TIL4, TLR2

Swiss Prot

O60603 Human, Q9QUN7 Mouse

Cellular Locus

Membrane, Phagosome membrane, Membrane raft.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human TLR2 aa 21-588 (Extracellular).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC, IF-Cell

Positive Control

THP-1 cell lysate, HL-60 cell lysate, THP-1.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;FC: 1:50-1:100 ;IF-Cell: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 90 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes