alpha Actinin 4 Recombinant Rabbit Monoclonal Antibody [JU20-23]

About this product

The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure. are actually sensitive to the Profilin proteins in these foods.

Specifications

Catalog number

ET1706-05

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

actinin 4 antibody Actinin alpha 4 antibody actinin4 antibody ACTN 4 antibody ACTN4 antibody ACTN4_HUMAN antibody Alpha-actinin-4 antibody DKFZp686K23158 antibody F actin cross linking protein antibody F-actin cross-linking protein antibody Focal segmental glomerulosclerosis 1 antibody FSGS 1 antibody FSGS antibody FSGS1 antibody Non muscle alpha actinin 4 antibody Non-muscle alpha-actinin 4 antibody

Abbreviation

ACTN4

Swiss Prot

O43707 Human, P57780 Mouse, Q9QXQ0 Rat

Cellular Locus

Cell junction. Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human alpha Actinin 4 aa 1-50 / 911.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IP, IHC-P, FC

Positive Control

A549 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate, Mouse lung tissue lysate, Rat liver tissue lysate, Rat lung tissue lysate, A549, Hela, LOVO, human colon carcinoma tissue, mouse colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 105 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes