macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83] — image 1 of 3

Product details

macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83]

Catalog number ET1706-15

Price for ET1706-15

Size / count 100 µL

About this product

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

Specifications

Catalog number: ET1706-15
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Core histone macro h2a.1 antibody Core histone macro-H2A.1 antibody H2A histone family member Y antibody H2A.y antibody H2A/y antibody H2AF12M antibody H2AFJ antibody H2afy antibody H2AY_HUMAN antibody Histone H2A.Y antibody Histone macroH2A1 antibody Histone macroH2A1.1 antibody Histone macroH2A1.2 antibody Macroh2a1 antibody MACROH2A1.1 antibody MacroH2A1.2 antibody Medulloblastoma antigen MU MB 50.205 antibody Medulloblastoma antigen MU-MB-50.205 antibody mH2a antibody mH2A1 antibody
Abbreviation: Histone macroH2A1, mH2A1, H2A/y, H2AFY, MACROH2A1
Swiss Prot: O75367 Human, Q9QZQ8 Mouse, Q02874 Rat
Cellular Locus: Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human macroH2A1 aa 232-281 / 369.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P
Positive Control: Hela, HepG2, PC-3M, human lung cancer tissue using anti-macroH2A.1 antibody. Counter stained, human thyroid gland tissue, human placenta tissue, mouse fallopian tube tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 40 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83]?

The catalog number for macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83] is ET1706-15.

What sizes are available for macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83]?

macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83] is available in the following size(s): 100 µL.

Is macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83] in stock?

macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83] is currently made to order / not held in immediate stock. Contact us for lead time.

What is macroH2A.1 Recombinant Rabbit Monoclonal Antibody [JU22-83] used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.