DDB1 Recombinant Rabbit Monoclonal Antibody [JU32-35]

About this product

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.

Specifications

Catalog number

ET1706-22

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Damage specific DNA binding protein 1 antibody Damage-specific DNA-binding protein 1 antibody DDB 1 antibody DDB p127 subunit antibody Ddb1 antibody DDB1_HUMAN antibody DDBa antibody DNA damage binding protein 1 antibody DNA damage-binding protein 1 antibody DNA damage-binding protein a antibody HBV X-associated protein 1 antibody UV damaged DNA binding factor antibody UV damaged DNA binding protein 1 antibody UV DDB 1 antibody UV DDB1 antibody UV-damaged DNA-binding factor antibody UV-damaged DNA-binding protein 1 antibody UV-DDB 1 antibody X associated protein 1 antibody XAP 1 antibody XAP-1 antibody XAP1 antibody Xeroderma pigmentosum group E complementing protein antibody Xeroderma pigmentosum group E-complementing protein antibody XPCe antibody XPE antibody XPE BF antibody XPE binding factor antibody XPE-BF antibody XPE-binding factor antibody

Abbreviation

DDBa, XAP-1, UV-DDB 1, XPE-BF, XPCe, DDB1, XAP1

Swiss Prot

Q16531 Human, Q3U1J4 Mouse, Q9ESW0 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human DDB1 aa 1040-1140 / 1,140.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

MCF7 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate, Neuro-2a cell lysate, PC-12 cell lysate, C6 cell lysate, PC-12, human kidney tissue, mouse brain tissue, rat esophagus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:1,000 ;IP: 1:10-1:50 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 127 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes