SAMHD1 Recombinant Rabbit Monoclonal Antibody [JU56-04]

About this product

SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, macrophages and monocytes. It is an enzyme that exhibits phosphohydrolase activity, converting deoxynucleoside triphosphates (dNTPs) to inorganic phosphate (iPPP) and a 2'-deoxynucleoside (i.e. deoxynucleosides without a phosphate group). In doing so, SAMHD1 depletes the pool of dNTPs available to a reverse transcriptase for viral cDNA synthesis and thus prevents viral replication. SAMHD1 has also shown nuclease activity. Although a ribonuclease activity was described to be required for HIV-1 restriction, recent data confirmed that SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity.

Specifications

Catalog number

ET1706-24

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CHBL2 antibody DCIP antibody Dendritic cell derived IFNG induced protein antibody Dendritic cell-derived IFNG-induced protein antibody Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 antibody dNTPase antibody HD domain containing 1 antibody HDDC1 antibody Mg11 antibody Monocyte protein 5 antibody MOP 5 antibody MOP-5 antibody MOP5 antibody OTTHUMP00000030889 antibody SAM domain and HD domain 1 antibody SAM domain and HD domain containing protein 1 antibody SAM domain and HD domain-containing protein 1 antibody SAMH1_HUMAN antibody Samhd1 antibody SBBI88 antibody

Abbreviation

dNTPase, DCIP, MOP-5, SAMHD1, MOP5

Swiss Prot

Q9Y3Z3 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human SAMHD1 aa 577-626 / 626.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

THP-1 cell lysates, HepG2, HUVEC, LOVO, human tonsil tissue tissue, human colon carcinoma tissue, human spleen tissue, K562.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

72 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes