NUP153 Recombinant Rabbit Monoclonal Antibody [JU40-41]

About this product

Nuclear pore complexes (NPCs) are the channels for the bi-directional movement of macromolecules between the nucleus and cytoplasm, and contain more than 100 different subunits. Many of them belong to a family called nucleoporins, which are characterized by the presence of O-linked N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup153 is a peripheral NPC component that is implicated in protein and RNP transport and in the interaction of NPCs with the nuclear lamina. Nup153 contains a unique N-terminal region, a central domain consisting of four to five zinc fingers and a C-terminal region containing about 30 irregularly spaced FXFG repeats. Nup153 is cleaved by caspases during apoptosis. Nup153 interacts wtih TAP, which is essential for mRNA export, and associates with chromatin towards the end of anaphase, in parallel with the inner nuclear membrane protein LAP2. Nup153 is involved in NPC assembly, in anchoring NPCs within the nuclear envelope and in mediating specific nuclear import events.

Specifications

Catalog number

ET1706-25

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

153 kDa nucleoporin antibody HNUP153 antibody N153 antibody NU153_HUMAN antibody Nuclear pore complex protein hnup153 antibody Nuclear pore complex protein Nup153 antibody Nucleoporin 153kDa antibody Nucleoporin Nup153 antibody Nup 153 antibody Nup153 antibody

Abbreviation

NUP153

Swiss Prot

P49790 Human

Cellular Locus

Nucleus, nuclear pore complex.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human NUP153 aa 51-100 / 1,475.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC

Positive Control

K562 cell lysate, HepG2 cell lysate, A431, Hela, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

154 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes