Transglutaminase 2 Recombinant Rabbit Monoclonal Antibody [JU30-02]

About this product

Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.

Specifications

Catalog number

ET1706-35

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ALPHA SUBUNIT antibody C polypeptide antibody EC 2.3.2.13 antibodyepididymis secretory protein Li 45 antibody G alpha h antibody G[a]h antibody Gh CLASS G ALPHA h antibody GNAH antibody GNAH G PROTEIN antibody H POLYPEPTIDE antibody HEL-S-45 antibody Protein glutamine gamma glutamyltransferase 2 antibody Protein-glutamine gamma-glutamyltransferase 2 antibody TG 2 antibody TG (C) antibody TG2 antibody TGase C antibody TGase H antibody TGase-2 antibody TgaseII antibody TGC antibody TGC GUANINE NUCLEOTIDE BINDING PROTEIN antibody TGM2 antibody TGM2_HUMAN antibody Tissue transglutaminase antibody Transglutaminase 2 antibody Transglutaminase 2 C polypeptide antibody Transglutaminase C antibody Transglutaminase H antibody Transglutaminase-2 antibody tTG antibody tTGas antibody

Abbreviation

TG (C), TGC, TGase C, TGase H, TGase-2, TGM2

Swiss Prot

P21980 Human, P21981 Mouse,

Cellular Locus

Cytosol. Plasma Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Transglutaminase 2 aa 578-627 / 687.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

K-562 cell lysate, HeLa cell lysate, HUVEC cell lysate, Mouse placenta tissue lysate, human placenta tissue, mouse placenta tissue, rat placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 77 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes