HDAC9 Recombinant Rabbit Monoclonal Antibody [JU30-44]

About this product

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription.

Specifications

Catalog number

ET1706-36

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

HD 7 antibody HD 7B antibody HD 9 antibody HD7 antibody HD7B antibody HD9 antibody HDAC 7 antibody HDAC 7B antibody HDAC 9 antibody HDAC 9B antibody HDAC 9FL antibody HDAC antibody HDAC7 antibody HDAC7B antibody HDAC9 antibody HDAC9_HUMAN antibody HDAC9B antibody HDAC9FL antibody HDRP antibody Histone deacetylase 4/5 related protein antibody Histone deacetylase 7 antibody Histone deacetylase 7B antibody Histone deacetylase 9 antibody Histone deacetylase 9A antibody Histone deacetylase related protein antibody Histone deacetylase-related protein antibody KIAA0744 antibody MEF2 interacting transcription repressor MITR antibody MEF2 interacting transcription repressor protein antibody MEF2-interacting transcription repressor MITR antibody MITR antibody

Abbreviation

HD9, HD7, HD7b, HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR

Swiss Prot

Q9UKV0 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human HDAC9 aa 1-50 / 1,011.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

RD cell lysate, K-562 cell lysate, K-562, A431, human brain tissue, human bladder cancer tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:500-1:2,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 111 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes