p23 Recombinant Rabbit Monoclonal Antibody [JU09-31]

About this product

P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ERα), a steroid complex, to its mature form and to regulate the expression of ERα-related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.

Specifications

Catalog number

ET1706-43

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Co chaperone p23 antibody cPGES antibody Cytosolic prostaglandin E synthase antibody Cytosolic prostaglandin E2 synthase antibody Hsp90 co chaperone antibody Hsp90 co-chaperone antibody P23 antibody Progesterone receptor complex antibody Progesterone receptor complex p23 antibody Prostaglandin E synthase 3 (cytosolic) antibody Prostaglandin E synthase 3 antibody PTGES 3 antibody PTGES3 antibody Sid 3177 antibody TEBP antibody TEBP_HUMAN antibody Telomerase binding protein p23 antibody Telomerase-binding protein p23 antibody Unactive progesterone receptor 23 kD antibody

Abbreviation

cPGES, PTGES3, P23, TEBP

Swiss Prot

Q15185 Human, Q9R0Q7 Mouse, P83868 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human p23 aa 43-92 / 160.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP

Positive Control

SK-Br-3 cell lysate, A431 cell lysate, A431, Hela, human tonsil tissue, human colon carcinoma tissue, mouse fallopian tube tissue, rat testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:100-1:500;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

23 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes