Alpha Fodrin Recombinant Rabbit Monoclonal Antibody [JU32-09]

About this product

Alpha Fodrin also named Spectrin. Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous α and β chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin α II, a neuronal cytoskeleton protein.

Specifications

Catalog number

ET1706-44

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

(ALPHA)II-SPECTRIN antibody Alpha II Spectrin antibody Alpha-II spectrin antibodybrain antibody EIEE5 antibody FLJ17738 antibody FLJ44613 antibody Fodrin alpha chain antibody Fodrin, alpha antibody NEAS antibody Non erythrocytic spectrin alpha antibody non-erythroid alpha chain antibody SPECA antibody Spectrin alpha chain antibody Spectrin alpha chain brain antibody Spectrin alpha non erythrocytic 1 antibody Spectrin antibody Spectrin non erythroid alpha chain antibody Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) antibody Spectrin, nonerythroid, alpha subunit antibody Spna2 antibody SPTA 2 antibody SPTA2 antibody SPTA2_HUMAN antibody SPTAN 1 antibody SPTAN1 antibody

Abbreviation

NEAS, SPTA2

Swiss Prot

Q13813 Human, P16546 Mouse, P16086 Rat

Cellular Locus

Cytoskeleton.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Alpha Fodrin aa 46-95 / 2,472.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, rat brain tissue lysate, mouse brain tissue lysate, human liver carcinoma tissue, human pancreas tissue, mouse cerebellum tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 285 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes