Growth hormone receptor Recombinant Rabbit Monoclonal Antibody [JU01-34]

About this product

GHR (growth hormone receptor) binds growth hormone (GH), which is produced by the anterior pituitary and regulates body growth and other metabolic processes. GHR is an integral membrane protein and a member of the cytokine receptor family. A common characteristic of the cytokine receptor family is having soluble forms of the protein. The soluble form of GHR is GH-binding protein (GHBP), which is generated by the proteolytic cleavage of the extracellular domain of GHR (2-4). Reduced levels of GHBP are associated with GH insensitivity syndrome (GHIS) (2,4). GHR has been shown to be transcribed via at least two different promoters, resulting in GHR 1A and GHR 1B. Both GHR 1A and 1B are expressed in liver, whereas GHR 1B is also expressed in muscle, uterus, and ovary tissues.

Specifications

Catalog number

ET1706-49

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

GH receptor antibody GH-binding protein antibody GHBP antibody GHBP, included antibody GHR antibody GHR_HUMAN antibody Growth hormone binding protein antibody Growth hormone receptor antibody Growth hormone receptor precursor antibody Growth hormone-binding protein antibody Growth hormone-binding protein, included antibody Increased responsiveness to growth hormone, included antibody Serum binding protein antibody Serum-binding protein antibody Somatotropin receptor antibody

Abbreviation

GH receptor, GH-binding protein, GHBP, GHR

Swiss Prot

P10912 Human, P16882 Mouse, P16310 Rat

Cellular Locus

Secreted. Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Growth hormone receptor aa 537-586 / 638.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IF-Tissue

Positive Control

Rat brain tissue lysate, mouse brain tissue lysate, human brain tissue lysate, A549, SH-SY-5Y, mouse liver tissue, MCF-7.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:1;000 ;FC: 1:50-1:100 ;IF-Tissue: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 72 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes