Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18] — image 1 of 3

Product details

Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18]

Catalog number ET1706-52

Price for ET1706-52

Size / count 100 µL

About this product

THOC1 (THO complex subunit 1), also known as Tho1, P84, HPR1 or P84N5, is a 657 amino acid nuclear matrix protein and is evolutionarily conserved from yeast to humans. THOC1 contains one death domain and is a component of the heteromultimeric THO/TREX (transcription/export) complex along with THOC2, THOC3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. THOC1 is expressed at high levels in breast cancer cells and at relatively low levels in normal epithelia. A reduction of THOC1 in cancer cell lines results in reduced cell proliferation. This suggests that cancer cells are dependent on the high levels of THOC1 expression and therefore THOC1 may be a good target for cancer therapy.

Specifications

Catalog number: ET1706-52
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: hTREX84 antibody Death domain containing protein p84N5 antibody HPR 1 antibody HPR1 antibody hTREX84 antibody Nuclear matrix protein p84 antibody P84 antibody p84N5 antibody Tho 1 antibody THO complex 1 antibody THO complex subunit 1 antibody Tho1 antibody THOC 1 antibody Thoc1 antibody THOC1_HUMAN antibody
Abbreviation: Tho1, p84N5, THOC1, HPR1
Swiss Prot: Q96FV9 Human, Q8R3N6 Mouse, P59924 Rat
Cellular Locus: Nucleus speckle,Nucleus, nucleoplasm,Nucleus matrix,Cytoplasm
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human Nuclear Matrix Protein p84 aa 367-416 / 657.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: Hela cell lysate, A431 cell lysate, Mouse skeletal muscle lysate, PC-12 cell lysate, HUVEC, LOVO, rat testis tissue, rat brain tissue, human colon carcinoma tissue, human tonsil tissue, human lung carcinoma tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 76 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18]?

The catalog number for Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18] is ET1706-52.

What sizes are available for Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18]?

Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18] is available in the following size(s): 100 µL.

Is Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18] in stock?

Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Nuclear Matrix Protein p84 Recombinant Rabbit Monoclonal Antibody [JU53-18] used for?

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.