RbAP48 Recombinant Rabbit Monoclonal Antibody [JU37-47]

About this product

In the intact cell, DNA is closely associated with histones and other nuclear proteins to form chromatin.The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation, and an increased accessiblity of DNA to transcription factors. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. The retinoblastoma binding proteins RbAp46 and RbAp48 have been identified as histone binding proteins, and they are components of the histone deacetylase complex.

Specifications

Catalog number

ET1706-54

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CAF I p48 antibody CAF-1 subunit C antibody CAF-I 48 kDa subunit antibody CAF-I p48 antibody Chromatin assembly factor 1 subunit C antibody Chromatin assembly factor I p48 subunit antibody Chromatin assembly factor/CAF 1 p48 subunit antibody Histone-binding protein RBBP4 antibody MSI1 protein homolog antibody Nucleosome-remodeling factor subunit RBAP48 antibody NURF55 antibody RB binding protein 4 chromatin remodeling factor antibody RbAp 48 antibody RBAP48 antibody RBBP-4 antibody RBBP4 antibody RBBP4_HUMAN antibody Retinoblastoma binding protein 4 antibody Retinoblastoma binding protein p48 antibody Retinoblastoma-binding protein 4 antibody Retinoblastoma-binding protein p48 antibody

Abbreviation

CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, RBBP-4, RBBP4, RBAP48

Swiss Prot

Q09028 Human, Q60972 Mouse

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human RbAP48 aa 1-98 / 425.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IP

Positive Control

NIH-3T3 cell lysate, Hela cell lysate, rat brain tissue lysate, mouse testis tissue lysate, Hela, MCF-7, SH-SY5Y, rat brain tissue, human tonsil tissue, mouse testis tissue, human lung carcinoma tissue, human liver tissue,Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100;IP:1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

48 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes