NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80] — image 1 of 3

Product details

NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80]

Catalog number ET7106-57

Price for ET7106-57

Size / count 100 µL

About this product

The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 (NCKα) and NCK2 (NCKβ), which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. Specifically, overexpression of Nck1 in NIH/3T3 cells decreases DNA synthesis stimulated by EGF. Furthermore, the SH2 domain of NCK2 inhibits EGF- and PDGF-induced DNA synthesis. The SH3 domain of NCK binds a proline-rich domain on PAK, a known actin cytoskeleton regulator. The NCK protein thus mediates the interaction between PAK and RAC. The NCK2 protein binds human PDGFR-b (Tyr 1009); overexpression of Nck2 inhibits PDGF-induced membrane ruffling and lamellipod formation. Various growth factor receptors, cell surface antigens and adhesion molecules phosphorylate mammalian NCK1 and NCK2. The human NCK1 and NCK2 genes map to chromosomes 3q22.3 and 2q12.2, respectively.

Specifications

Catalog number: ET7106-57
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Cytoplasmic protein NCK1 antibody Melanoma Nck protein antibody MGC12668 antibody NCK 1 antibody NCK adaptor protein 1 antibody NCK alpha antibody NCK antibody NCK tyrosine kinase antibody Nck-1 antibody NCK1 antibody NCK1_HUMAN antibody NCKalpha antibody Non catalytic region of tyrosine kinase antibody SH2/SH3 adaptor protein NCK alpha antibody SH2/SH3 adaptor protein NCK-alpha antibody
Abbreviation: Nck-1, NCK1, NCK
Swiss Prot: P16333 Human, Q99M51 Mouse, B2RZ33 Rat
Cellular Locus: Cytoplasm. Endoplasmic reticulum. Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human NCK1 aa 204-296 / 377.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Positive Control: Hela cell lysate, NIH/3T3 cell lysate, rat kidney tissue lysate, mouse testis tissue lysate, LOVO, A431, HUVEC, mouse testis tissue, rat testis tissue, human tonsil tissue, human kidney tissue, Jurkat.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100;IP: 1:10-1:50
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 43 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80]?

The catalog number for NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80] is ET7106-57.

What sizes are available for NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80]?

NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80] is available in the following size(s): 100 µL.

Is NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80] in stock?

NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80] is currently made to order / not held in immediate stock. Contact us for lead time.

What is NCK1 Recombinant Rabbit Monoclonal Antibody [JU41-80] used for?

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.