IGFBP2 Recombinant Rabbit Monoclonal Antibody [JU37-46]

About this product

The Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain.

Specifications

Catalog number

ET7106-63

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

BP 2 antibody BP2 antibody IBP 2 antibody IBP-2 antibody IBP2 antibody IBP2_HUMAN antibody IGF binding protein 2 antibody IGF BP53 antibody IGF-binding protein 2 antibody IGFBP 2 antibody IGFBP-2 antibody IGFBP2 antibody IGFBP53 antibody Insulin like growth factor binding protein 2 36kDa antibody Insulin like growth factor binding protein 2 antibody Insulin like growth factor-binding protein 2 precursor antibody Insulin-like growth factor-binding protein 2 antibody

Abbreviation

IBP-2, IGF-binding protein 2, IGFBP-2, IGFBP2, BP2, IBP2

Swiss Prot

P18065 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal Human IGFBP2 .

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Human serum lysate, NCCIT, human liver tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes