TRP1 Recombinant Rabbit Monoclonal Antibody [JU36-48]

About this product

Tyrosinase (TYR), a type I membrane protein and copper-containing enzyme, is involved in the production of melanin, the primary pigment found in vertebrates. Melanin biogenesis requires the enzymatic activity of TYR, which catalyzes the critical and rate-limiting step of tyrosine hydroxylation in the biosynthesis of melanin. Defects effecting TYR activity result in various forms of albinism. The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteine-rich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exists as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.

Specifications

Catalog number

ET7106-66

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

5 antibody 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody 6-dihydroxyindole-2-carboxylic acid oxidase antibody b-PROTEIN antibody CAS2 antibody Catalase B antibody CATB antibody DHICA oxidase antibody Glycoprotein 75 antibody GP75 antibody Melanoma antigen gp75 antibody OCA3 antibody TRP antibody TRP-1 antibody TRP1 antibody Tyrosinase related protein 1 antibody Tyrosinase-related protein 1 antibody TYRP antibody TYRP1 antibody TYRP1_HUMAN antibody TYRRP antibody

Abbreviation

DHICA oxidase, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP

Swiss Prot

P17643 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human TRP1 aa 411-537 / 537.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP

Positive Control

Melanoma tissue lysates, HUVEC, A431, human skin tissue, human malignant melanoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:500 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

72 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes