Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13] — image 1 of 2

Product details

Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13]

Catalog number ET7106-69

Price for ET7106-69

Size / count 100 µL

About this product

Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD2 (for mitotic arrest-deficient) is a component of the mitotic spindle checkpoint. Cells with mutated MAD2 do not undergo mitotic arrest in response to incorrect spindle fiber assembly, which results in missegregation and eventual cell death. A breast carcinoma cell line with reduced MAD2 expression, T47D, was shown to complete mitosis in the presence of nocodazole, an inhibitor of mitotic spindle assembly. MAD2 is localized to unattached kinetochores during prometaphase and disassociates upon spindle fiber attachment, indicating that MAD2 regulates kinetochore binding to the spindle fibers. Human MAD2 has also been shown to associate with insulin receptor (IR), but not IGFIR, implicating MAD2 as a mediator for IR-specific signaling. MAD2B, a MAD2 homolog, is required for the execution of the mitotic checkpoint monitoring the kinetochore-spindle attachment process and if the process is not complete, MAD2B delays the onset of anaphase.

Specifications

Catalog number: ET7106-69
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Caught by MAD2 protein antibody CMT2 antibody dJ261G23.1 antibody KIAA0110 antibody MAD2L1 binding protein antibody MAD2L1 binding protein isoform 2 antibody MAD2L1-binding protein antibody Mad2l1bp antibody MD2BP_HUMAN antibody MGC11282 antibody OTTHUMP00000016496 antibody RP1 261G23.6 antibody
Abbreviation: HsMAD2, MAD2-like protein 1, MAD2L1, MAD2
Swiss Prot: Q13257 Human
Cellular Locus: Nucleus. Cytoskeleton.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human Mad2L1 aa 69-124 / 205.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell
Positive Control: K562, 293T, SH-SY5Y.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000;IF-Cell: 1:100-1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 23.5 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13]?

The catalog number for Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13] is ET7106-69.

What sizes are available for Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13]?

Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13] is available in the following size(s): 100 µL.

Is Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13] in stock?

Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Mad2L1 Recombinant Rabbit Monoclonal Antibody [JU46-13] used for?

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.