GAB1 Recombinant Rabbit Monoclonal Antibody [JU47-19]

About this product

Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway.

Specifications

Catalog number

ET7106-70

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Gab 1 antibody GAB1 antibody GAB1_HUMAN antibody GRB 2 associated binder 1 antibody GRB 2 associated binding protein 1 antibody GRB2 associated binding protein 1 isoform a antibody GRB2 associated binding protein 1 isoform b antibody GRB2-associated binder 1 antibody GRB2-associated-binding protein 1 antibody Growth factor receptor bound protein 2-associated protein 1 antibody

Abbreviation

GAB1

Swiss Prot

Q13480 Human

Cellular Locus

Cytosol.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human GAB1 aa 450-500 .

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Human small intestine tissue lysate, LOVO, MCF-7, SH-SY5Y, human skin tissue, rat epididymis tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

77 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes