BDKRB2 Recombinant Rabbit Monoclonal Antibody [JU39-04]

About this product

Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.

Specifications

Catalog number

ET7106-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

B2 antibody B2 bradykinin receptor antibody B2BKR antibody B2BRA antibody B2R antibody BDKR B2 antibody BDKRB 2 antibody BDKRB2 antibody BK 2 antibody BK 2 receptor antibody BK R2 antibody BK-2 receptor antibody BK2 antibody BK2 receptor antibody BK2R antibody BKR 2 antibody BKR2 antibody BKRB2_HUMAN antibody BR B2 antibody Bradykinin receptor B2 antibody Bradykinin receptor beta 2 antibody BRB 2 antibody BRB2 antibody DKFZp686O088 antibody Kinin B2 antibody

Abbreviation

B2R, BK-2 receptor, BDKRB2, BKR2

Swiss Prot

P30411 Human,P32299 Mouse

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within Human BDKRB2 aa 262-391 / 391.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC, IP, IHC-P, IF-Cell

Positive Control

Neuro-2a cell lysates, MCF-7 cell lysates, mouse brain tissue, Neuro-2a, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;FC: 1:1:1,000 ;IP: 1-2μg/sample ;IHC-P: 1:200 ;IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes