SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34]

Catalog number ET7106-76

Price for ET7106-76

Size / count 100 µL

About this product

Smurf1 and Smurf2 (SMAD ubiquitination regulatory factor-1 and 2) are members of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway, which targets proteins for degradation by the 26S proteasome. Within the Ub pathway, the E3 ligases specifically catalyze the transfer of Ub from the Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated SMADs specific to the BMP pathway in order to trigger their ubiquitination and degradation. Smurf2 interacts with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3, but not Smad4. Although Smurf2 localizes to the nucleus, binding to Smad7 induces its export and its recruitment to the activated TGFβ receptor, where it causes degradation of Smad7.

Specifications

Catalog number: ET7106-76
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: E3 ubiquitin-protein ligase SMURF2 antibody EC 6.3.2. antibody hSMURF2 antibody MGC138150 antibody Smad specific E3 ubiquitin ligase 2 antibody SMAD specific E3 ubiquitin protein ligase 2 antibody SMAD ubiquitination regulatory factor 2 antibody SMAD-specific E3 ubiquitin-protein ligase 2 antibody SMUF2_HUMAN antibody Smurf2 antibody Ubiquitin protein ligase SMURF2 antibody
Abbreviation: hSMURF2, SMURF2
Swiss Prot: Q9HAU4 Human
Cellular Locus: Cytoplasm. Membrane. Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human SMURF 2 aa 150-340.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: A431.
Concentration: 1 mg/mL
Dilution: WB: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 86 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34]?

The catalog number for SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34] is ET7106-76.

What sizes are available for SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34]?

SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34] is available in the following size(s): 100 µL.

Is SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34] in stock?

SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34] used for?

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.