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![EB3 Recombinant Rabbit Monoclonal Antibody [JU38-30] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea81660/imageurl/et7106-99.webp)
Product details
Catalog number ET7106-99
Price for ET7106-99
Size / count 100 µL
EB1 (MAPRE2, microtubule-associated protein, RP/EB family, member 2, EB2, RP1) may influence tumorigenesis of colorectal cancers and proliferative control of normal cells. EB1 may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Colorectal cancer is caused by the pathologic transformation of normal colonic epithelium to an adenomatous polyp, which can become an invasive cancer. APC (adenomatous polyposis coli) is a tumor suppressor gene, the mutation of which is one of the earliest events in colorectal carcinogenesis. A majority of the mutations result in the loss of the carboxy terminus of APC. EB1 has been shown to bind to the carboxy terminal region of APC, which implicates EB1 in APC suppression of colonic cancer. EB1 overexpression may play a role in the development of human esophageal squamous cell carcinoma (ESCC) by affecting APC function and activating the beta-catenin/TCF pathway. EB3 is related to EB1 and likewise associates with the microtubule cytoskeleton. EB3 is expressed predominantly in the central nervous system and preferentially associates with APCL.
The catalog number for EB3 Recombinant Rabbit Monoclonal Antibody [JU38-30] is ET7106-99.
EB3 Recombinant Rabbit Monoclonal Antibody [JU38-30] is available in the following size(s): 100 µL.
EB3 Recombinant Rabbit Monoclonal Antibody [JU38-30] is currently made to order / not held in immediate stock. Contact us for lead time.
EB1 (MAPRE2, microtubule-associated protein, RP/EB family, member 2, EB2, RP1) may influence tumorigenesis of colorectal cancers and proliferative control of normal cells. EB1 may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Colorec
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Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
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