RING2 Recombinant Rabbit Monoclonal Antibody [JB38-41]

About this product

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable).

Specifications

Catalog number

ET7107-07

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

BAP 1 antibody BAP1 antibody DING antibody DinG protein antibody E3 ubiquitin protein ligase RING 2 antibody E3 ubiquitin protein ligase RING2 antibody E3 ubiquitin-protein ligase RING2 antibody HIP2 interacting protein 3 antibody HIP2-interacting protein 3 antibody HIPI 3 antibody HIPI3 antibody Huntingtin interacting protein 2 interacting protein 3 antibody Huntingtin-interacting protein 2-interacting protein 3 antibody OTTHUMP00000060668 antibody Polycomb M33 interacting protein Ring 1B antibody Polycomb M33 interacting protein Ring1B antibody Protein DinG antibody RING 1B antibody RING 2 antibody RING finger protein 1B antibody RING finger protein 2 antibody RING finger protein BAP 1 antibody RING finger protein BAP-1 antibody RING finger protein BAP1 antibody RING1b antibody RING2_HUMAN antibody RNF 2 antibody Rnf2 antibody

Abbreviation

HIP2-interacting protein 3, RING1b, RNF2, BAP1, DING, HIPI3, RING1B

Swiss Prot

Q99496 Human

Cellular Locus

Chromosome. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human RING2 aa 83-256 .

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

K562 cell lysate, human placenta tissue, human breast carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes