GABRA5 Recombinant Rabbit Monoclonal Antibody [JB34-19]

About this product

Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.

Specifications

Catalog number

ET7107-08

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

GAA 5 antibody GAA5 antibody GABA (A) receptor subunit alpha-5 antibody GABRA 5 antibody Gabra5 antibody Gamma aminobutyric acid GABA A receptor alpha 5 antibody Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody Gamma-aminobutyric acid receptor subunit alpha-5 antibody GBRA5_HUMAN antibody GC138184 antibody

Abbreviation

Gamma-aminobutyric acid receptor subunit alpha-5, GABA (A) receptor subunit alpha-5, GABAAR subunit alpha-5, GABRA5

Swiss Prot

P31644 Human, Q8BHJ7 Mouse, P19969 Rat

Cellular Locus

Postsynaptic cell membrane, Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human GABRA5 aa 1-240 / 462.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P

Positive Control

A549 cell lysate, Neuro-2a cell lysate, C6 cell lysate, Mouse brain tissue lysate, mouse brain tissue, rat brain tissue, mouse cerebellum tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Tissue: 1:500 ;IHC-P: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 52 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes