hnRNP U Recombinant Rabbit Monoclonal Antibody [JB23-43]

About this product

Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Specifications

Catalog number

ET7107-10

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Heterogeneous nuclear ribonucleoprotein U antibody hnRNP U antibody hnRNP U protein antibody HNRNPU antibody hnRNPU protein antibody HNRPU antibody HNRPU_HUMAN antibody p120 antibody p120 nuclear protein antibody pp120 antibody SAF A antibody SAF-A antibody SAFA antibody Scaffold attachment factor A antibody U21.1 antibody

Abbreviation

hnRNP U, SAF-A, HNRNPU, C1orf199, HNRPU, SAFA, U21.1

Swiss Prot

Q00839 Human, Q8VEK3 Mouse, Q6IMY8 Rat

Cellular Locus

Nucleus. Cytoskeleton.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinantpeptide within Human hnRNP U aa 1-140 / 825.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

NIH/3T3 cell lysate, SH-SY5Y cell lysate, K562 cell lysate, A431, HepG2, SH-SY5Y, rat brain tissue, human tonsil tissue, human lung carcinoma tissue, human kidney tissue, mouse colon tissue, human cervix tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human breast tissue, human breast carcinoma tissue, human esophagus tissue, human placenta tissue, mouse bladder tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:400

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 91 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes