SET Recombinant Rabbit Monoclonal Antibody [JB60-34] — image 1 of 3

Product details

SET Recombinant Rabbit Monoclonal Antibody [JB60-34]

Catalog number ET7107-18

Price for ET7107-18

Size / count 100 µL

About this product

Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Specifications

Catalog number: ET7107-18
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 2PP2A antibody HLA DR associated protein II antibody HLA-DR-associated protein II antibody I 2PP2A antibody I-2PP2A antibody I2PP2A antibody IGAAD antibody Inhibitor of granzyme A activated DNase antibody Inhibitor of granzyme A-activated DNase antibody Inhibitor of GzmA-activated DNase antibody inhibitor-2 of protein phosphatase-2A antibody IPP2A2 antibody PHAPII antibody Phosphatase 2A inhibitor I2PP2A antibody protein phosphatase type 2A inhibitor antibody Protein SET antibody Set antibody SET nuclear oncogene antibody SET translocation antibody SET translocation (myeloid leukemia-associated) antibody SET_HUMAN antibody TAF I antibody TAF IBETA antibody TAF-I antibody TAFI antibody Template activating factor I antibody Template-activating factor I antibody Template-Activating Factor-I, chromatin remodelling factor antibody
Abbreviation: IGAAD, I-2PP2A, TAF-I, SET
Swiss Prot: Q01105 Human, Q9EQU5 Mouse
Cellular Locus: Nucleus. Cytoplasm. Endoplasmic reticulum.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within Human SET aa 160-290 / 290.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IHC-P, IP, IF-Tissue
Positive Control: Rat kidney tissue, human tonsil tissue, mouse fallopian tube tissue, human lung carcinoma tissue, human kidney tissue, K-562 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: 1-2μg/sample ;IF-Tissue: 1:50
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 33 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SET Recombinant Rabbit Monoclonal Antibody [JB60-34]?

The catalog number for SET Recombinant Rabbit Monoclonal Antibody [JB60-34] is ET7107-18.

What sizes are available for SET Recombinant Rabbit Monoclonal Antibody [JB60-34]?

SET Recombinant Rabbit Monoclonal Antibody [JB60-34] is available in the following size(s): 100 µL.

Is SET Recombinant Rabbit Monoclonal Antibody [JB60-34] in stock?

SET Recombinant Rabbit Monoclonal Antibody [JB60-34] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SET Recombinant Rabbit Monoclonal Antibody [JB60-34] used for?

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.