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Product details

Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32]

Catalog number ET7107-19

Price for ET7107-19

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Size / count 100 µL

About this product

Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Mast Cell Chymase, also known as CMA1 or MCT1, is a major secreted serine protease that is involved in vasoactive peptide generation, extracellular matrix degradation and regulation of gland secretion. The human chymase gene, which maps to human chromosome 14q11.2, encodes a preproenzyme with a 19 amino acid signal peptide, an acidic 2 amino acid propeptide and a 226 amino acid catalytic domain. Mast Cell Chymase is a chymotryptic serine proteinase which is a member of the peptidase family S1. Expressed in mast cells, Mast Cell Chymase is associated with the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. Mast cell proteases are a family of rodent protein homologs to human tryptases that are specifically expressed in mast cells and may serve as highly specific markers in the analysis of mast cell heterogeneity, differentiation and function. Mast Cell Protease 1, also designated Mcp-1 or Mcpt1, is a rodent specific beta-chymase. The mouse and rat Mast Cell Protease 1 proteins share 76% sequence identity at the amino acid level.

Specifications

Catalog number
ET7107-19
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9000-83-3
Product Name Alternative
Alpha-chymase antibody Chymase 1 antibody Chymase 1 mast cell antibody chymase 1 preproprotein transcript E antibody chymase 1 preproprotein transcript I antibody Chymase antibody Chymase, heart antibody Chymase, mast cell antibody CMA1 antibody CMA1_HUMAN antibody CYH antibody CYM antibody EC 3.4.21.39 antibody Mast cell chymase 1 antibody Mast cell protease 3 antibody Mast cell protease 5 antibody Mast cell protease I antibody Mast cell protease III antibody Mcp-5 antibody MCP3P antibody Mcpt5 antibody MCT1 antibody MGC119890 antibody MGC119891 antibody MMCP-5 antibody
Abbreviation
CMA1, CYH, CYM
Swiss Prot
P23946 Human, P21844 Mouse, P50339 Rat
Cellular Locus
Secreted, Cytoplasmic granule.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human Mast Cell Chymase aa 198-247 / 247.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Mouse spleen tissue lysate, rat spleen tissue lysate, human skin tissue, human tonsil tissue, human small intestine tissue, human lymph nodes tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:200-1:800
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 27 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes

Frequently Asked Questions

What is the catalog number for Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32]?

The catalog number for Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32] is ET7107-19.

What sizes are available for Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32]?

Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32] is available in the following size(s): 100 µL.

Is Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32] in stock?

Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody [JB74-32] used for?

Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Mast Cell Chymase, also known as CMA1 or MCT1, is a major secreted serine protease that is involved in vasoactive peptide genera

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

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