Proteasome 20S LMP2 Recombinant Rabbit Monoclonal Antibody [JB35-07]

About this product

Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.

Specifications

Catalog number

ET7107-24

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Beta1i antibody Large multifunctional peptidase 2 antibody Large multifunctional protease 2 antibody LMP 2 antibody LMP2 antibody Low molecular mass protein 2 antibody Macropain chain 7 antibody MGC70470 antibody Multicatalytic endopeptidase complex chain 7 antibody OTTHUMP00000062982 antibody Proteasome (prosome macropain) subunit beta type 9 antibody proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) antibody Proteasome beta 9 subunit antibody Proteasome catalytic subunit 1i antibody Proteasome chain 7 antibody Proteasome related gene 2 antibody Proteasome subunit beta 6i antibody Proteasome subunit beta type 9 antibody Proteasome subunit beta type-9 antibody Proteasome subunit beta-1i antibody PSB9_HUMAN antibody PSMB 9 antibody PSMB6i antibody PSMB9 antibody Really interesting new gene 12 protein antibody RING 12 antibody RING12 antibody RING12 protein antibody

Abbreviation

PSMB9, LMP2, PSMB6i, RING12

Swiss Prot

P28065 Human, P28076 Mouse

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within Human Proteasome 20S LMP2 aa 85-219 / 219.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

Mouse spleen tissue lysate, U937 cell lysate, mouse colon tissue lysate, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 23 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes