Ikaros Recombinant Rabbit Monoclonal Antibody [JB50-38]

About this product

Ikaros is a transcription factor that is encoded by the IKZF genes of the Ikaros family zinc finger group. Zinc finger is a small structural motif of protein that allows protein binding to DNA or RNA molecule that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. Ikaros displays crucial functions in the hematopoietic system and is a known regulator of immune cells development, mainly in early B cells, CD4+ T cells. Its dysfunction has been linked to the development of chronic lymphocytic leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia and that it also has a part in the differentiation and function of individual T helper cells. Ikaros also has a role during the later stages of B cell development during VDJ recombination in switch class of the antibody isotypes and expression of the B cell receptor. SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood acute lymphoblastic leukemia (ALL) as well as type 1 diabetes. The two effects appear to be in opposite directions, with the allele marking susceptibility to ALL protecting from T1D and vice versa.

Specifications

Catalog number

ET7107-25

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CLL associated antigen KW 6 antibody DNA-binding protein Ikaros antibody hIk 1 antibody Hs.54452 antibody IK1 antibody Ikaros (zinc finger protein) antibody IKAROS antibody IKAROS family zinc finger 1 (Ikaros) antibody Ikaros family zinc finger protein 1 antibody Ikzf1 antibody IKZF1_HUMAN antibody LYF1 antibody Lymphoid transcription factor LyF-1 antibody PRO0758 antibody Zinc finger protein subfamily 1A 1 (Ikaros) antibody Zinc finger protein subfamily 1A 1 antibody Zinc finger protein, subfamily 1A, member 1 antibody ZNFN1A1 antibody

Abbreviation

IKZF1, IK1, IKAROS, LYF1, ZNFN1A1

Swiss Prot

Q13422 Human, Q03267 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Ikaros aa 261-353 / 519.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Raji cell lysate, Daudi cell lysate, rat colon tissue, human spleen tissue, mouse spleen tissue, human tonsil tissue, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:1,000 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 58 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes