Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] — image 1 of 3

Product details

Securin Recombinant Rabbit Monoclonal Antibody [JB37-37]

Catalog number ET7107-50

Price for ET7107-50

Size / count 100 µL

About this product

Securin is a protein that in humans is encoded by the PTTG1 gene. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Specifications

Catalog number: ET7107-50
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: AW555095 antibody C87862 antibody Cut2 antibody EAP 1 antibody EAP1 antibody ESP1 associated protein 1 antibody Esp1-associated protein antibody hPTTG antibody MGC126883 antibody MGC138276 antibody Pds1 antibody Pituitary tumor transforming 1 antibody Pituitary tumor transforming protein 1 antibody Pituitary tumor-transforming 1, isoform CRA_a antibody Pituitary tumor-transforming 1, isoform CRA_b antibody Pituitary tumor-transforming gene 1 antibody Pituitary tumor-transforming gene 1 protein antibody PTTG 1 antibody PTTG antibody PTTG1 antibody PTTG1 protein antibody PTTG1_HUMAN antibody Pttg3 antibody Securin antibody Tumor transforming 1 antibody Tumor transforming protein 1 antibody Tumor-transforming protein 1 antibody TUTR 1 antibody TUTR1 antibody
Abbreviation: Tumor-transforming protein 1, hPTTG, PTTG1, EAP1, PTTG, TUTR1
Swiss Prot: O95997 Human, Q6IAL9 Human
Cellular Locus: Cytoplasm. Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within C-terminal Human Securin .
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, FC, IP
Positive Control: SiHa cell lysate, A431, HUVEC, PC-3M, human tonsil tissue, human colon cancer tissue, human testis tissue, human lymph nodes tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 22 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Securin Recombinant Rabbit Monoclonal Antibody [JB37-37]?

The catalog number for Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] is ET7107-50.

What sizes are available for Securin Recombinant Rabbit Monoclonal Antibody [JB37-37]?

Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] is available in the following size(s): 100 µL.

Is Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] in stock?

Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Securin Recombinant Rabbit Monoclonal Antibody [JB37-37] used for?

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.