USP7 Recombinant Rabbit Monoclonal Antibody [JB80-36]

About this product

Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene. USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[9] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP activity generally stabilizes its substrate proteins. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. A possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults. USP7 can deubiquitinate histone H2B and this activity is associated with gene silencing in Drosophila. USP7 associates with a metabolic enzyme, GMP synthetase (GMPS) and this association stimulates USP7 deubiquitinase activity towards H2B. The USP7-GMPS complex is recruited to the polycomb (Pc) region in Drosophila and contributes to epigenetic silencing of homeotic genes.

Specifications

Catalog number

ET7107-53

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Deubiquitinating enzyme 7 antibody HAUSP antibody Herpes virus associated ubiquitin specific protease antibody Herpesvirus-associated ubiquitin-specific protease antibody TEF 1 antibody tef-1 antibody TEF1 antibody Ubiquitin carboxyl terminal hydrolase 7 antibody Ubiquitin carboxyl-terminal hydrolase 7 antibody Ubiquitin specific peptidase 7 (herpes virus associated) antibody Ubiquitin specific peptidase 7 antibody Ubiquitin specific peptidase 7 herpes virus associated antibody Ubiquitin specific processing protease 7 antibody Ubiquitin specific protease 7 (herpes virus associated) antibody Ubiquitin specific protease 7 antibody Ubiquitin specific protease 7 herpes virus associated antibody Ubiquitin thioesterase 7 antibody Ubiquitin thiolesterase 7 antibody Ubiquitin-specific-processing protease 7 antibody UBP 7 antibody UBP-7 antibody UBP7 antibody UBP7_HUMAN antibody USP 7 antibody usp-7 antibody Usp7 antibody VMW110-ASSOCIATED PROTEIN, 135-KD antibody

Abbreviation

USP7

Swiss Prot

Q93009 Human, Q6A4J8 Mouse, Q4VSI4 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human USP7 aa 80-180 / 1,102.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Wild-type A375 whole cell lysates, 293T cell lysates, HeLa cell lysates, rat brain tissue, human tonsil tissue, mouse colon tissue, PC-3M.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 128 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes