Galectin 8 Recombinant Rabbit Monoclonal Antibody [JB85-35]

About this product

Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene. This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. Galectin-8, interacts with the mTOR regulatory system composed of SLC38A9, Ragulator, RagAB, RagCD. Galectin-8 controls mTOR causing its inactivation and dissociation from damaged lysosomes, hence transducing the breach of the lysosomal membrane to mTOR. The physiological consequences of mTOR inhibition following lysosomal membrane damage[8] encompass autophagy and metabolic switching.

Specifications

Catalog number

ET7107-56

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Gal 8 antibody Gal-8 antibody Gal8 antibody Galectin-8 antibody galectin-8g antibody Lectin galactoside binding soluble 8 antibody LEG8_HUMAN antibody LGAL S8 antibody Lgals8 antibody PCTA 1 antibody PCTA-1 antibody PCTA1 antibody Po66 carbohydrate binding protein antibody Po66 carbohydrate-binding protein antibody Po66 CBP antibody Po66-CBP antibody Prostate carcinoma tumor antigen 1 antibody

Abbreviation

Gal-8, Po66-CBP, PCTA-1, LGALS8

Swiss Prot

O00214 Human, Q9JL15 Mouse, Q62665 Rat

Cellular Locus

Cytosol.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Galectin 8 aa 1-50 / 317.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P, IP

Positive Control

Mouse testis tissue lysate, rat testis tissue lysate, A431, HepG2, human kidney tissue, human liver tissue, human colon carcinoma tissue, PC-3M.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Tissue: 1:400-1:800 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 36 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes