Huntingtin Recombinant Rabbit Monoclonal Antibody [JB89-34]

About this product

Huntingtin (Htt) is the protein coded for by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage. It is variable in its structure, as the many polymorphisms of the gene can lead to variable numbers of glutamine residues present in the protein. In its wild-type (normal form), it contains 6-35 glutamine residues. However, in individuals affected by Huntington's disease (an autosomal dominant genetic disorder), it contains more than 36 glutamine residues (highest reported repeat length is about 250). Its commonly used name is derived from this disease; previously, the IT15 label was commonly used. Within cells, huntingtin may or may not be involved in signaling, transporting materials, binding proteins and other structures, and protecting against apoptosis, a form of programmed cell death. The huntingtin protein is required for normal development before birth. It is expressed in many tissues in the body, with the highest levels of expression seen in the brain.

Specifications

Catalog number

ET7107-60

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AI256365 antibody C430023I11Rik antibody HD antibody HD protein antibody HD_HUMAN antibody HDH antibody HTT antibody Huntingtin antibody HUNTINGTON CHOREA antibody Huntington disease protein antibody Huntington's disease protein homolog antibody IT 15 antibody IT15 antibody OTTMUSP00000026909 antibody ZHD antibody

Abbreviation

HD protein, HTT, HD, IT15

Swiss Prot

P42858 Human, P42859 Mouse, P51111 Rat

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within N-terminal Human Huntingtin .

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC, IHC-Fr, IF-Cell, IF-Tissue

Positive Control

Neuro-2a cell lysate, PC-12 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, human colon carcinoma tissue, human breast tissue, mouse epididymis tissue, rat brain tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:5,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IHC-Fr: 1:100 ;IF-Cell: 1:100 ;IF-Tissue: 1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 348 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes