FKBP51 Recombinant Rabbit Monoclonal Antibody [JB95-39]

About this product

The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin. The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGFβ-type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGFβ pathway. FKBP51 and FKBP52 are two highly related proteins. FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids. FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation. FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8).

Specifications

Catalog number

ET7107-64

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

51 kDa FK506 binding protein 5 antibody 51 kDa FK506 binding protein antibody 51 kDa FK506-binding protein antibody 51 kDa FKBP antibody 54 kDa progesterone receptor associated immunophilin antibody 54 kDa progesterone receptor-associated immunophilin antibody AIG 6 antibody AIG6 antibody Androgen regulated protein 6 antibody Androgen-regulated protein 6 antibody FF1 antigen antibody FK506 binding protein 5 antibody FK506-binding protein 5 antibody FKBP 5 antibody FKBP 51 antibody FKBP 54 antibody FKBP-5 antibody FKBP-51 antibody FKBP5 antibody FKBP5_HUMAN antibody FKBP54 antibody HSP90 binding immunophilin antibody HSP90-binding immunophilin antibody MGC111006 antibody OTTHUMP00000016268 antibody P54 antibody Peptidyl prolyl cis trans isomerase antibody Peptidyl-prolyl cis-trans isomerase FKBP5 antibody Peptidylprolyl cis trans isomerase antibody PPIase antibody PPIase FKBP5 antibody Ptg 10 antibody Ptg10 antibody Rotamase antibody T cell FK506 binding protein antibody

Abbreviation

PPIase FKBP5, 51 kDa FKBP, FKBP-51, FKBP-5, p54, FKBP5, AIG6, FKBP51

Swiss Prot

Q13451 Human, Q5U2T9 Rat

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within human FKBP51 aa 400-440.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP, FC

Positive Control

Daudi cell lysate, Hela cell lysate, human tonsil tissue, human kidney tissue, rat lung tissue, Daudi.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes