CPS1 Recombinant Rabbit Monoclonal Antibody [JB40-33]

About this product

The multicomplex protein, carbamoyl-phosphate synthetase-aspartate carbamoyl transferase-dihydro-orotase (CAD), consists of three distinct proteins, carbamoyl phosphate synthetase 2 (CPS2), aspartate transcarbamylase, and dihydro-orotase, which catalyze the second and third steps of pyrimidine biosynthesis. CAD is allosterically regulated by the phosphorylation of CPS2 by cyclic AMP-dependent protein kinase, and this activation enables CPS2 to catalyze the rate-limiting step of pyrimidine synthesis. CAD is expressed in brain and skeletal muscle. A related protein, carbamoyl phosphate synthetase 1 (CPS1) is expressed in liver. CPS1 catalyzes the rate-limiting step in the urea cycle, and deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia.

Specifications

Catalog number

ET7107-69

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Carbamoyl phosphate synthase [ammonia] antibody Carbamoyl phosphate synthase [ammonia] mitochondrial antibody Carbamoyl phosphate synthase antibody Carbamoyl phosphate synthetase 1 antibody Carbamoyl phosphate synthetase 1 mitochondrial antibody Carbamoyl phosphate synthetase I antibody Carbamoyl-phosphate synthase [ammonia] antibody Carbamoyl-phosphate synthetase I antibody Carbamoylphosphate synthase antibody Carbamoylphosphate synthetase 1 antibody Carbamoylphosphate synthetase I antibody CPS 1 antibody Cps1 antibody CPSase 1 antibody CPSase I antibody CPSASE1 antibody CPSM_HUMAN antibody mitochondrial antibody MS738 antibody

Abbreviation

CPSase I, CPS1

Swiss Prot

P31327 Human, Q8C196 Mouse, P07756 Rat

Cellular Locus

Mitochondrion, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human CPS1 aa 82-204 / 1,500.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP

Positive Control

HepG2 cell lysate, HeLa cell lysate, mouse small intestine tissue lysate, rat liver tissue lysate, HepG2, human liver tissue, mouse liver tissue, rat liver tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 165 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes