DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46] — image 1 of 3

Product details

DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46]

Catalog number ET7107-83

Price for ET7107-83

Size / count 100 µL

About this product

Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Cultured normal human keratinocytes express dsg1 and dsg3 mRNA, with or without dsg 2 mRNA, which indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules dsg 1 and 3 and acetylcholine receptors.

Specifications

Catalog number: ET7107-83
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Cadherin family member 4 antibody CDHF4 antibody Desmoglein-1 antibody Desmosomal glycoprotein 1 antibody DG1 antibody DGI antibody DSG antibody DSG1 antibody DSG1_HUMAN antibody EPKHE antibody EPKHIA antibody Pemphigus foliaceus antigen antibody PPKS1 antibody SPPK1 antibody
Abbreviation: DG1, DGI, DSG1, CDHF4
Swiss Prot: Q02413 Human, Q61495 Mouse
Cellular Locus: Cell membrane.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic peptide within Human DSG1 aa 1,000-1,049 / 1,049.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: Human skin tissue, human colon cancer tissue, human uterus tissue, mouse skin tissue.
Concentration: 1 mg/mL
Dilution: IHC-P: 1:200-1:1,000 ;WB: 1:500
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 114 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46]?

The catalog number for DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46] is ET7107-83.

What sizes are available for DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46]?

DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46] is available in the following size(s): 100 µL.

Is DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46] in stock?

DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DSG1 Recombinant Rabbit Monoclonal Antibody [JB19-46] used for?

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.