CD46 Recombinant Rabbit Monoclonal Antibody [JB25-49]

About this product

CD46, also called membrane cofactor protein (MCP), is a transmembrane glycoprotein that exists as a non-disulfide-linked dimer. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. CD46 is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocytes. It is the major high affinity receptor for measles virus and human herpes virus. Mouse cells ubiquitously express CRRY, which is a functional ortholog of human decay-accelerating factor (DAF; CD55) and membrane cofactor protein (MCP; CD46).

Specifications

Catalog number

ET7107-94

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AHUS2 antibody Antigen defined by monoclonal antibody TRA 2 10 antibody Antigen identified by monoclonal antibody TRA 2 10 antibody CD46 antibody CD46 antigen antibody CD46 antigen complement regulatory protein antibody CD46 molecule antibody CD46 molecule complement regulatory protein antibody Complement membrane cofactor protein antibody MCP antibody MCP_HUMAN antibody Measles virus receptor antibody membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody Membrane cofactor protein antibody MGC26544 antibody MIC10 antibody TLX antibody TRA2.10 antibody Trophoblast leucocyte common antigen antibody Trophoblast leukocyte common antigen antibody Trophoblast lymphocyte cross reactive antigen antibody

Abbreviation

CD46, MCP, MIC10

Swiss Prot

P15529 Human, Q9Z0M4 Rat

Cellular Locus

Acrosome inner membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within Human CD46 aa 31-80 / 392.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

SiHa cell lysate, PC-3M cell lysate, PC-3M, HUVEC, human colon carcinoma tissue, human colon tissue, human breast tissue, human placenta tissue, rat kidney tissue, human prostate tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:800

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes